Fine-scale Identification of the Most Likely Source of a Human Plague Infection

نویسندگان

  • Rebecca E. Colman
  • Amy J. Vogler
  • Jennifer L. Lowell
  • Kenneth L. Gage
  • Christina Morway
  • Pamela J. Reynolds
  • Paul Ettestad
  • Paul Keim
  • Michael Y. Kosoy
  • David M. Wagner
چکیده

We describe an analytic approach to provide fine-scale discrimination among multiple infection source hypotheses. This approach uses mutation-rate data for rapidly evolving multiple locus variable-number tandem repeat loci in probabilistic models to identify the most likely source. We illustrate the utility of this approach using data from a North American human plague investigation.

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عنوان ژورنال:

دوره 15  شماره 

صفحات  -

تاریخ انتشار 2009